Immune Status

The immune status of the patient can alter the expression of the disease.

Consider zoster (shingles) infection. In immunocompromised patients, such as a patient with AIDS, the infection can present with erosions, ulcers, eschars, or even papules rather than the typical vesicles seen in the immunocompetent patient.

With scabies, an immunocompromised patient may develop a more severe case, called crusted scabies, than an immunocompetent patient.